Efficacy of Sildenafil as a Rescue Therapy for Patients With Severe Pulmonary Arterial Hypertension and Given Long-term Treatment With Prostanoids: 2-Year Experience

Adjunct sildenafil to long-term prostacyclin therapy in patients with severe PAH provided sustained clinical stabilization and an improved clinical situation, exercise capacity and echocardiographic parameters of right ventricular function. The beneficial effects were strong and lasted >24 months.