| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2973264 | The Journal of Heart and Lung Transplantation | 2006 | 7 Pages |
Abstract
The data show that high myocardial collagenase (MMP1 and MMP8) expression without compensatory changes in collagen or TIMP expression is a feature of patients requiring LVAD support. This may be linked in part to elevated cytokine expression and suggests collagenase activity may be an important therapeutic target in deteriorating heart failure.
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Authors
Leanne E. BSc, Emma J. MRCP, PhD, Robert MRCS, Sissie PhD, Asghar FRCS, Magdi H. FRS, Paul J.R. PhD,