| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2973360 | The Journal of Heart and Lung Transplantation | 2006 | 7 Pages |
Abstract
The significant decrease in serum BNP concentration after LVAD support coincides with a decrease in BNP mRNA and protein expression in the heart. BNP is produced in the left ventricle not only by cardiomyocytes but also by endothelial cells, T cells, and macrophages. Unloading of the left ventricle by a LVAD results in decreased BNP expression in the heart and plasma and may play an important role in the reverse remodeling process of the heart.
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Authors
Annette H. MSc, Nicolaas MD, PhD, Matthijs F.M. MD, PhD, Dick F. BSc, Erica BSc, Jaap R. MD, BSc, Hans PhD, Frits H.J. PhD, Roel A. PhD,