| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2973498 | The Journal of Heart and Lung Transplantation | 2006 | 9 Pages |
Abstract
Positive inotropy of insulin was not related to catecholamine release and subsequent stimulation of β-adrenergic receptor, but it may enhance the activity of SR Ca2+-ATPase and trans-sarcolemmal Ca2+ entry, mainly via reverse-mode Na+-Ca2+ exchange and insulin-mediated activation of Na+-H+ exchange. We hypothesize that these changes in [Ca2+]i might be secondary to the activation of reverse-mode Na+-Ca2+ exchange, presumably via elevated intracellular Na+ concentration.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Chih-Hsueng MD, Jeng MD, Yao-Chang MSc, Shih-Ping MD, PhD, Chien-Song MD, Cheng-I. PhD,