Assessment of γ-GT functions as novel risk factor in patients suffering from angina, myocardial infarction and congestive heart failure

BackgroundCardiovascular disease is a leading cause of morbidity and mortality both in developed and developing country. The spectrum of cardiac diseases starting from hypertension to acute coronary syndrome is interplay of a number of modifiable and non-modifiable risk factors. Free radicals triggering oxidative events influence atherosclerotic plaque formation and thereby, initiate the vicious cycle of cardiovascular mortality. Traditionally, GGT (gamma glutamyl transferase) is used as marker of hepatobiliary dysfunction and alcohol intake. With the advent of biomedical science the last decade has seen the development in the physiological role of γ-GT related to oxidative stress. GGT is established as novel, low-cost, sensitive laboratory marker in the definition of risk factor for coronary heart disease and ischeamia in Australian, Norwegian population.ObjectivesThe objective of this study was to estimate the serum concentration of GGT in patients suffering from myocardial infarction, angina and congestive heart failure and to see its association with cardiovascular mortality.MethodIn this cross-sectional study serum GGT concentration was estimated in patients of myocardial infarction, angina and congestive heart failure and compared with control group. All the study subjects were evaluated with ECG and Echocardiography for cardiac changes. Statistical analysis was performed using SPSS 16 to see whether GGT is increased in cases and associated with the risk factors.ResultsThe serum concentration of GGT was significantly higher in cases. There was significant association with the established risk factors.ConclusionGGT is associated with risk factors of cardiovascular disease.