To study inverse relationship between serum total bilirubin levels and severity of disease in patients with stable coronary artery disease as assessed by coronary angiography and syntax score

Serum bilirubin concentrations in the upper portion of the reference value (0.61-1.0 mg/dl) reduce atherogenic risk and provide protection against CAD. In contrast, serum bilirubin concentrations in the lower portion of the reference value (0-0.60 mg/dl) may be associated with increased risk of CAD. The evidence presented in our study supports the concept that bilirubin, via its antioxidant potential, has antiatherogenic properties and that an inverse relationship exists between circulating bilirubin concentrations and risk of CAD.