Hypertension intracrânienne idiopathique et mutation du facteur V de Leiden

Activated protein C resistance is a frequent prothrombotic abnormality. In most cases it is due to factor V Leiden mutation by nucleotide G1691A substitution. This recently described thrombophilic defect of activated protein C resistance has been postulated to be implicated in the pathogenesis of idiopathic intracranial hypertension (IIH). We report a case of factor V Leiden mutation in association with IIH and their likely link and implication in the management of IIH.