Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2979587 | The Journal of Thoracic and Cardiovascular Surgery | 2015 | 10 Pages |
Abstract
Compared with monolayer cell culture, the in vitro 3-D tumor spheroid model better reflects the superior in vivo efficacy of Pax-eNPs. Persistent tumor penetration and prolonged intratumoral release are unique mechanisms of Pax-eNP cytotoxicity. 3-D spheroid models are valuable tools for investigating cytotoxic mechanisms and nanoparticle-tumor interactions, particularly given the costs and limitations of in vivo animal studies.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Hongyi MD, PhD, Sophie C. MBBS, Rong MD, PhD, Aaron PhD, Kristie M. BS, Paul ScD, Mark W. PhD, Yolonda L. MD, PhD,