Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2980085 | The Journal of Thoracic and Cardiovascular Surgery | 2015 | 9 Pages |
Abstract
Supraphysiologic shear stress alone causes physical demolition of large von Willebrand factor multimers into smaller von Willebrand factor multimers. In the setting of supraphysiologic shear stress, ADAMTS-13 cleaves large von Willebrand factor multimers into von Willebrand factor degradation fragments. ADAMTS-13 may be a therapeutic target to reduce von Willebrand factor degradation and bleeding complications in patients with a left ventricular assist device.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Carlo R. MD, PhD, David J. BSE, David M. Zhang, Michael A. MD, Pavan MD,