Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2980157 | The Journal of Thoracic and Cardiovascular Surgery | 2015 | 9 Pages |
Abstract
Astrocytes have been shown to preserve neuronal viability via release of neurotrophic factors. Dexmedetomidine increases glial cell-derived neurotrophic factor from spinal cord astrocytes via the alpha-2 receptor. Treatment with alpha-2 agonist dexmedetomidine may be a clinical tool for use in spinal cord protection in aortic surgery.
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Authors
Kirsten A. MD, David A. MD, Lisa S. MD, Marshall T. MD, Joseph C. MD, Michael J. MD, Joshua BA, Xianzhong PhD, MD, Ferenc MD, PhD, T. Brett MD,