Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation

Article ID	Journal	Published Year	Pages	File Type
2980162	The Journal of Thoracic and Cardiovascular Surgery	2015	10 Pages	PDF

Abstract

Our study has prioritized GPX1, NOX3, and NFE2L2 genes for future research in PGD pathogenesis, and highlights a donor-recipient interaction of NOX3 and NFE2L2 that increases the risk of PGD.

Keywords

NOS1AP SKAT NOX3 Gstm2 NOS3 NFE2L2 GPx1 PGD PON1 HWE MDS MAF ROS Acute lung injury primary graft dysfunction Ali COPD Chronic obstructive pulmonary disease Hardy-Weinberg equilibrium Linkage disequilibrium minor allele frequencies Multidimensional scaling Single nucleotide polymorphism SNP Reactive oxygen species

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Oxidant stress regulatory genetic variation in recipients and donors contributes to risk of primary graft dysfunction after lung transplantation

Authors

Edward MD, Rupal J. MD, Wei PhD, Zhongyin J. PhD, MS, Joshua M. MD, MSCE, Yoshikazu MD, MS, John H. BA, Catherine F. BA, Gerald A. BA, Ben BA, Nuala J. MD, MS, Melanie BA, Richard MD, MS, Rui PhD, Jason D. MD, MS,