| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2980305 | The Journal of Thoracic and Cardiovascular Surgery | 2013 | 16 Pages |
Abstract
These data collectively highlight a previously unrecognized role of BRCA1 as a gatekeeper of inflammation-induced endothelial cell function and a target to limit atherosclerosis. Translational studies evaluating endothelial function and atherosclerosis in individuals with BRCA1 mutations are suggested.
Keywords
33.1oxLDLVCAM-1TNFαeNOSHUVECDOXICAM-1GAPDHFITCGFPMOISmall interfering RNAROSsiRNAAdenovirustumor necrosis factor-alphaDoxorubicinHuman umbilical vein endothelial cellEndothelial cellendothelial nitric oxide synthaseCMVcytomegalovirusVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)fluorescein isothiocyanateOxidized low-density lipoproteinIntercellular adhesion molecule 1Vascular cell adhesion molecule 1plaque-forming unitpolymerase chain reactionPCRgreen fluorescent proteinpfuSingle nucleotide polymorphismSNPmultiplicity of infectionglyceraldehyde 3-phosphate dehydrogenaseReactive oxygen species
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Authors
Krishna K. PhD, Praphulla C. PhD, Adrian MPhil, Mohammed MD, MSc, FRCSC, Fina PhD, Yi MD, Christine MD, PhD, FRCPC, Alistair J. MD, William L. PhD, Hwee PhD, Subodh MD, PhD, FRCSC,