Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2981218 | The Journal of Thoracic and Cardiovascular Surgery | 2013 | 9 Pages |
Abstract
MR is expressed in human venous tissue and cells and modulates gene expression in HSVSMC in response to physiologic aldosterone concentrations. In vivo, MR inhibition reduces vein graft thickening and inflammation. These preclinical data support the potential to use MR antagonists as novel treatments to preserve vein graft patency.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Afshin MD, Adam P. PhD, Mark J. MS, Carol BS, Michael S. MD, Richard H. MD, PhD, Iris Z. MD, PhD,