| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2982247 | The Journal of Thoracic and Cardiovascular Surgery | 2011 | 12 Pages |
Abstract
Bone marrow stromal cell-derived factor 1 upregulation after myocardial ischemia prevents mobilization of endogenous hematopoietic progenitor cells. We provide evidence that disruption of stromal cell-derived factor 1/CXC chemokine receptor 4 interactions allows redirection of hematopoietic progenitor cells to ischemic myocardium and enhances recovery of left ventricular function.
Keywords
CXCR4stromal cell–derived factor 1IL-8SCFSDF-1HPCmAbRT–PCRMonoclonal antibodyMyocardial infarctionInterleukin 8Hematopoietic progenitor cellgranulocyte colony-stimulating factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Stem Cell FactorG-CSFLADMHCmajor histocompatibility complexreverse transcriptase–polymerase chain reactionpolymerase chain reactionPCRleft anterior descending coronary arteryCXC chemokine receptor 4
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Authors
Nikolaos MD, PhD, Hugo MS, MD, Dominik MD, Bernhard MD, Thomas MD, Michael MSc, Tetsunori PhD, Timothy P. MD, Silviu MD, Alfred A. MD,