| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2982328 | The Journal of Thoracic and Cardiovascular Surgery | 2012 | 10 Pages |
Abstract
MCARD-mediated βARKct delivery is safe, results in robust cardiac-specific gene expression, enhances cardiac contractility and lusitropy, increases adrenergic reserve, and improves energy utilization efficiency in a preclinical large animal model.
Keywords
GRKβ-adrenergic receptor kinaseβARKend-systolic pressure–volume relationshipG protein–coupled receptor kinasescAAVPmaxβARβARKctESPVRRT-qPCRGFPCPBcAMPdP/dtCyclic adenosine monophosphateMRIISOisoproterenolcardiopulmonary bypassLeft ventricularMagnetic resonance imagingreal-time quantitative polymerase chain reactiongreen fluorescent proteinβ-Adrenergic receptor
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Authors
Michael G. MD, PhD, Anthony S. MS, JaBaris D. MD, Catherine E. MD, Michele MD, Z. Maggie PhD, Joseph E. PhD, Charles R. MD, ScD,