Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2982890 | The Journal of Thoracic and Cardiovascular Surgery | 2011 | 11 Pages |
Abstract
In porcine coronary arteries, hypoxia markedly reduced endothelial K+ currents related to IKCa and SKCa with downregulation of protein expression and endothelium-derived hyperpolarizing factor function. IKCa/SKCa activator may preserve endothelium-dependent hyperpolarizing factor-mediated relaxation with enhancement of K+ current in endothelial cells and cellular membrane potential hyperpolarization in smooth muscle cells and may become a new strategy to protect coronary endothelium in cardiac surgery or transplantation.
Keywords
NG-nitro-l-arginineinward rectifier K+ channelsSKCaL-NNA1-ethyl-2-benzimidazolinoneHypoxia–reoxygenationPGI2EDHFI-R31.4KCa1-EBIOOxyhemoglobinKirHbOBKCaIKCaIndomethacinischemia–reperfusionanalysis of varianceANOVAconfidence intervalEndothelium-derived hyperpolarizing factorNitric oxideindoprostacyclinCalcium-activated potassium channels
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Authors
Qin MD, PhD, Jun-Hao MPhil, Yu-Bun MPhil, Xiao-Qiang PhD, Guo-Wei MD, PhD, DSc,