| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2983746 | The Journal of Thoracic and Cardiovascular Surgery | 2010 | 7 Pages |
Abstract
Expression of angiotensin II receptor type 1 but not type 2 is highly upregulated only in the left atrial tissue of patients with rheumatic valvular disease with atrial fibrillation. This suggests that there is a possible pathophysiologic role of the renin-angiotensin system in patients with atrial fibrillation and that a series of effects mediated by the activation of angiotensin II receptor type 1 in the left atrial tissue might be one of the molecular mechanisms involved in the process of atrial remodeling in atrial fibrillation.
Keywords
PBSAT1-Rangiotensin II receptor type 2ARBRASACEGAPDHRT–PCRAngiotensin-converting enzymeLeft atriumRight atriumSinus rhythmRenin–angiotensin systemAtrial fibrillationPhosphate-buffered salineAngiotensin receptor blockerACEI یا angiotensin convert enzyme inhibitorangiotensin-converting enzyme inhibitorreverse transcription–polymerase chain reactionpolymerase chain reactionPCRglyceraldehyde-3-phosphate dehydrogenaseangiotensin II receptor type 1
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Authors
Hongliang MD, PhD, Ximing MD, PhD, Lijun MD, Hua MD, Yongmin Mao, Meilin Xu,