Overactivation of poly(adenosine phosphate-ribose) polymerase 1 and molecular events in neuronal injury after deep hypothermic circulatory arrest: Study in a rabbit model

Article ID	Journal	Published Year	Pages	File Type
2986770	The Journal of Thoracic and Cardiovascular Surgery	2007	12 Pages	PDF

Abstract

This study demonstrated that deep hypothermic circulatory arrest results in an overactivation of poly(adenosine diphosphate-ribose) polymerase 1, and that there were molecular events consisting of cellular energy failure, excitotoxicity, overactivation of poly(adenosine diphosphate-ribose) polymerase 1, and necrosis and/or apoptosis in neuronal injury.

Keywords

PBS PARP-1 CPB ADP DHCA NAD+Adenosine Triphosphate ATP adenosine diphosphate cardiopulmonary bypass Par TUNEL standard error of the mean Deep hypothermic circulatory arrest Phosphate-buffered saline SEM NAD, nicotinamide adenine dinucleotide Poly(ADP-ribose)