Coarctation-induced degenerative abdominal aortic aneurysm in a porcine model

The present study demonstrates that persistent hemodynamic stress participates in the progression of aneurysmal degeneration. Moderate coarctation not only increases regional hemodynamic stress on the terminal aorta but also creates an asymmetric and angulated inflow tract similar to the tortuous aneurysm neck. Restoring normal flow pattern in the aneurysm sac as well as reducing regional hemodynamic stress by correcting the tortuous neck may prevent or reverse further aneurysmal degeneration. This porcine abdominal aortic aneurysm model provides a versatile platform to investigate abdominal aortic aneurysm pathogenesis and to develop new therapeutics.