Trimetazidine reduces early and long-term effects of experimental renal warm ischemia: A dose effect study

Our results suggest that TMZ limits in a dose-dependent manner IRI after 60 minutes of WI. This drug could be useful to prevent deleterious consequences of renal ischemia accompanied by a nephronic mass reduction (which mimic clinical situation of patients with chronic nephropathy who are at risk for vascular diseases), during thoracoabdominal aortic surgery, or operations with a planned period of WI (renal artery by-pass, juxta or supra-renal and thoracoabdominal aneurysm repair and promote renal recovery in a preclinical model.