Angiogenic properties of sustained release platelet-rich plasma: Characterization in-vitro and in the ischemic hind limb of the mouse

PRP is a natural reserver of various growth factors that can be collected autologously and is cost effective. Thus for clinical use, no special considerations concerning antibody formation and infection risk are needed. Some clinical devices to automatically prepare PRP are available at present. PRP are consistently being used clinically in the department of orthopedics and plastic surgery (oral, maxillary facial) for a long time. On the basis of research evidence, some publications have reported positive results in either bone or soft tissue healing. However, some research concludes that there is no or little benefit from PRP. This is likely due to faster degradation of growth factors in PRP since some authors suggest using sustained release form of PRP to deliver optimal effect of PRP. Gelatin hydrogel is also being used clinically as a slow, sustained release of carrier for growth factors in our center recently.