Article ID Journal Published Year Pages File Type
3002700 Nutrition, Metabolism and Cardiovascular Diseases 2010 7 Pages PDF
Abstract

Background and aimsTo examine whether the association between the −514 C/T polymorphism of the hepatic lipase gene and myocardial infarction (MI) is modified by history of hypercholesterolemia and increased waist circumference.Methods and resultsA total of 1940 pairs of nonfatal MI cases and population-based controls were genotyped. Multiple conditional logistic regression was used for data analyses. The −514T variant was not associated with MI in the whole population. However, among people with history of hypercholesterolemia the T allele increased MI risk for heterozygous and homozygous carriers, respectively [OR = 1.25 (95%CI = 0.92–1.70) and OR = 1.59 (95%CI = 1.09–2.32). In contrast, the T allele decreased MI risk among people with no history of hypercholesterolemia [OR = 0.85 (95%CI = 0.70–1.03) and OR = 0.76 (95%CI = 0.60–0.97)], p for interaction = 0.004. Among subjects with normal waist circumference there was no association between the −514T allele and MI for heterozygous and homozygous carriers, respectively [OR = 1.04 (95%CI = 0.86–1.25) and OR = 0.96 (95%CI = 0.77–1.21)], while among subjects with waist circumference above the limits of the metabolic syndrome definition there was a protective association [OR = 0.63 (95%CI = 0.45–0.90) and OR = 0.81 (95%CI = 0.53–1.25) p for interaction = 0.04].ConclusionThe −514 T allele is associated with MI in opposite directions depending on the background of the studied population. This could explain what seem like inconsistent results across studies.

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