Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3010839 | Resuscitation | 2007 | 4 Pages |
Abstract
The effects of vasopressin on the gut in a porcine uncontrolled haemorrhagic shock model are described. In eight anaesthetised pigs, a liver laceration was performed; when haemorrhagic shock was decompensated, all animals received 0.4 IU/kg vasopressin, followed by 0.08 IU/kg min over 30 min, which maintained a mean arterial blood pressure >40 mmHg. Subsequent surgical intervention, infusion of whole blood and fluids resulted in a stable cardiocirculatory status. Three hours after stabilisation, all pigs developed non-bloody diarrhoea which converted into normal bowel movements within 24 h. All histological samples retained 7 days after the experiment revealed no histopathological changes. In conclusion, in this small observational study of uncontrolled porcine haemorrhagic shock, a resuscitation strategy that included high dose vasopressin was associated with transient diarrhoea and good long term survival.
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Authors
Karl H. Stadlbauer, Volker Wenzel, Horst G. Wagner-Berger, Anette C. Krismer, Alfred Königsrainer, Wolfgang G. Voelckel, Claus Raedler, Christian A. Schmittinger, Karl H. Lindner, Guenter Klima,