| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3026796 | Thrombosis Research | 2016 | 5 Pages |
Abstract
Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed review we discuss recent advances in our understanding of the novel intracellular and extracellular functions of platelet FXIII-A.
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Authors
Joanne L. Mitchell, Nicola J. Mutch,