| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3026810 | Thrombosis Research | 2016 | 5 Pages |
Abstract
The daily production of billions of platelets must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Complex mechanisms control platelet production and clearance in physiological and pathological conditions. This review will focus on the mechanisms of platelet senescence with specific emphasis on the role of post-translational modifications in platelet life-span and thrombopoietin production downstream of the hepatic Ashwell-Morrell receptor.
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Authors
Karin M. Hoffmeister, Hervé Falet,