Impaired fibrin gel permeability by high homocysteine levels

Plasma incubated with high homocysteine concentrations produced fibrin clots significantly less permeable than controls in a dose dependent manner, and the results showed that fibrinogen and factor XIII were involved in that detrimental effect. These findings might explain the impaired fibrinolysis related to increased homocyteine levels and contribute to understanding the association between the amino acid and thrombosis.