A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia

Article ID	Journal	Published Year	Pages	File Type
3029250	Thrombosis Research	2008	9 Pages	PDF

Abstract

Our study confirms the combination of the 4T's score with the ID-H/PF4 PaGIA® as a reliable strategy to rule out HIT. Yet, confirming positive ID-H/PF4 PaGIA® results by flow cytometry within 1-2Â h after blood sampling remains necessary. This novel clinical-laboratory approach can contribute in a rapid and reliable way to the definite diagnosis of HIT.

Keywords

PBS confidence interval.LR-Platelet P-selectin CD62P ECD PPV PF4 LMWH PrP LR+enzyme-linked immunosorbent assays positive predictive value negative predictive value HIT HIPA Heparin-induced thrombocytopenia ELISA Min Sra intermediate risk minutes High risk Low risk Platelet factor 4 phycoerythrin Phosphate buffered saline Flow cytometry NPV یا negative predictive value positive likelihood ratio negative likelihood ratio low-molecular-weight heparin platelet-rich plasma optical density