Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Article ID	Journal	Published Year	Pages	File Type
3029565	Thrombosis Research	2009	10 Pages	PDF

Abstract

Asymptomatic members of FCH families have increased endothelial haemostatic factors- vWF, PAI-1, t-PA, which are associated with insulin resistance. VWF correlates with morphological vascular changes, detected by the increase of IMT, presented in only hyperlipidemic subjects.

Keywords

HDL-C APOE2 IRMA FCH apoB FMD CHD PAI-1 Apolipoprotein E2 RIA hs-CRP IMT LDL-C CCA ACE HDL DBP SBP immunoradiometric assay angiotensin converting enzyme Apolipoprotein B Homeostasis model assessment coronary heart disease analysis of variance ANOVA Enzyme-linked immunosorbent assay ELISA Flow mediated dilatation High sensitivity C Reactive Protein atherogenic index body mass index BMI common carotid artery Intima-media thickness non-HDL-C diastolic blood pressure systolic blood pressure high density lipoprotein low density lipoprotein LDL Plasminogen activator inhibitor-1 HOMA familial combined hyperlipidemia HDL cholesterol LDL-cholesterol Non-HDL cholesterol