Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3029680 | Thrombosis Research | 2008 | 8 Pages |
Abstract
Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed.
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Authors
María José Santos-Martínez, Carlos Medina, Paul Jurasz, Marek W. Radomski,