Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3030015 | Thrombosis Research | 2007 | 9 Pages |
Abstract
The similar biochemical and cellular responses in HCAEC exposed to thrombin or tryptase stimulation suggest that the cleavage of two separate PAR serve to extend the range of proteases to which the cells respond rather than resulting in separate intracellular events. This suggests that in conditions such as thrombosis and atherosclerosis that multiple mechanisms can activate the inflammatory response.
Keywords
PBSarachidonyl trifluoromethyl ketoneAACOCF3iPLA2BELPKCFCSHCAECEGTABSAAtherosclerosisbovine serum albuminEDTAethylenediamine tetraacetic acidinflammationEndotheliumbromoenol lactoneThrombinTryptaseParminimal essential mediumdiacylglycerolDAGfetal calf serumhuman coronary artery endothelial cellsPlatelet-activating factorPhosphate buffered salinePhosphatidate phosphohydrolasecalcium-independent phospholipase A2MEMPAFprotease activated receptorProtein kinase Cmitogen-activated protein kinaseMAP kinase
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Authors
Maureen C. White, Jane McHowat,