Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3035577 | Autonomic Neuroscience | 2007 | 9 Pages |
Abstract
Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-hydroxytryptamine (5-HT) and activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also trigger reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders.
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Authors
Jianjing Xue, Candice Askwith, Najma H. Javed, Helen J. Cooke,