Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3037883 | Brain and Development | 2010 | 7 Pages |
Abstract
Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hereditary spastic paraparesis (HSP) patients. The results showed that plasma SOD, vitamin E and nitric oxide levels were significantly low in HSP patients. These findings indicate the influence of oxidative damage in the degenerative process of HSP.
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Authors
Kıvılcım Gücüyener, F. Güçlü Pınarlı, Deniz Erbaş, Alev Hasanoğlu, Ayşe Serdaroğlu, Haluk Topaloğlu,