Prevotella brain abscess in a healthy young patient with a patent foramen ovale

•Brain abscess caused by isolated Prevotella species are very rare.•Most of cases of etiologies of Prevotella brain abscess are odontogenic.•Patent foramen ovale (PFO) may cause of brain abscess.•We report Prevotella brain abscess patient who had PFO without dental disease.

Brain abscesses are frequently caused by poly-microbial conditions. Comparatively, brain abscesses caused by Prevotella species are very rare. Right-to-left cardiac shunting due to a patent foramen ovale may predispose patients to infection. We report an isolated Prevotella brain abscess that occurred in a healthy, young, male patient with a patent foramen ovale. The patient did not have a clinically obvious odontogenic source of infection, and no other distant extracranial infectious sources were observed. The patient was successfully treated with stereotactic aspiration and antibiotics