| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3039637 | Clinical Neurology and Neurosurgery | 2016 | 14 Pages |
•Multiple sclerosis remains a clinical diagnosis supported by McDonald diagnostic criteria.•Ruling out mimickers of multiple sclerosis is important to reach the diagnosis with high accuracy.•A personalized treatment approach based on risk versus benefit analysis is recommended.•A multi-disciplinary team approach has been increasingly utilized in management of MS patients.
ObjectivesWe aim to develop consensus recommendations to guide neurologists in the community for the diagnosis and treatment of Multiple Sclerosis (MS).MethodsAfter reviewing the available literature, a group of neurologists with expertise in MS met to discuss the evidence and develop consensus recommendations for the diagnosis and treatment of MS.ResultsThe revised 2010 McDonald criteria is the established diagnostic criteria for MS and has wide international acceptance among international MS experts. Several red flags in the history and examination, along with certain laboratory tests were pointed out to exclude MS mimickers in the diagnostic phase. The available approved disease modifying therapies (DMTs) were listed in an algorithmic fashion based on initial assessment of disease severity and subsequent disease breakthrough while on DMTs. Risk stratification based on the benefit versus risk ratio was used to help choosing the appropriate therapy to MS patients using an “individualized therapy” approach. The requirements for initiation and monitoring of treated MS patients were highlighted with emphasis on early identification of disease breakthrough, adverse events, and safety concerns. The role of multi-disciplinary MS clinics was discussed and a guide for referral to specialized MS clinics was developed.ConclusionsConsensus recommendations have been developed to guide local neurologists on the diagnosis and treatment of patients with MS. Implementation of the revised 2010 McDonald diagnostic criteria was advised while a personalized treatment approach was recommended using a treatment algorithm based on risk stratification and patient-centered outcomes.
