| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3040139 | Clinical Neurology and Neurosurgery | 2015 | 6 Pages |
•We reported the progression of operated disk fungal infections to multiple spinal levels after discectomy.•Postsurgical fungal discitis may not be resolved with surgical debridement.•An insufficient course of antifungal medicine may play a role in progression of this condition.•Treatment may be prolonged antifungal treatment with regular consultation by an infectious disease specialist.
ObjectiveTo report multiple cases and investigate etiology of initially single fungal spondylodiscitis that progressively spread to adjacent segments following lumbar discectomy, resulting in multiple spinal involvements.MethodsFrom January 2005 to May 2013, ten adult patients were admitted or referred to our institution with postoperative discitis. Fungal infections were confirmed by microbiologic and pathologic examinations. The clinical appearance, radiographic features, and treatments of this pathology were investigated.ResultsAll the patients were previously healthy. The average interval between the occurrence of symptoms and primary lumbar discectomy was 61 days (range, 15–120 days). All the patients were treated with anterior surgical debridement, interbody fusion, and prolonged antifungal therapy. Three patients additionally received combined posterior instrumented fusion. Despite aggressive surgical debridement and antifungal therapy, spread of the infections to adjacent multiple discs was observed. No deaths, severe neurologic deficits, or deterioration of neurologic status were noted. The infections were completely resolved in all cases with spontaneous fusion within an average follow-up of 32.4 months.ConclusionFungal spondylodiscitis after surgery represents an intractable and troublesome complication, and surgical debridement may not impede the progression of the infection in cases where an insufficient course of antifungal treatment is administered. Such cases may require prolonged antifungal treatment with regular consultation by an infectious disease specialist.
