| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3041211 | Clinical Neurology and Neurosurgery | 2010 | 8 Pages |
PurposeThe authors analyzed the characteristics of perfusion magnetic resonance imaging (MRI), 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and 11C-methionine (MET) PET to compare the efficacies of these modalities in making the distinction between radiation necrosis and tumor recurrence of high-grade glioma.Patients and methodsTen patients were evaluated with dynamic susceptibility contrast perfusion MRI, 11C-MET PET and 18F-FDG PET to visualize gadolinium-enhanced lesions during the post-radiation follow-up period. In the perfusion MRI, four regions of interest (ROIs) were identified and average values were calculated. A reference ROI of the same size was defined in the contralateral white matter to obtain the relative cerebral blood volume (rCBV). After coregistering the PET images with the MRI, we measured the maximum uptake values of the lesion and of the contralateral cerebral white matter as reference area to calculate the Lmax/Rmax ratio.ResultsThe rCBV was higher in the recurrence group than in the necrosis group (p = 0.010). There was no difference between groups in terms of the Lmax/Rmax ratio as derived from the 18F-FDG and 11C-MET PET.ConclusionA quantitative rCBV as calculated from a perfusion MRI scan might be superior to the Lmax/Rmax ratio as derived from 18F-FDG and 11C-MET PET in order to distinguish a recurrence of high-grade glioma from radiation necrosis.
