Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3041323 | Clinical Neurology and Neurosurgery | 2010 | 4 Pages |
Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by the JC virus; the mortality rate is high and it is usually refractory to treatment. In non-HIV patients, PML occurs as a late consequence of hematologic malignancies or during prolonged immunosuppression for transplantation or autoimmune disease. We describe a 34-year-old PML patient with incomplete Heerfordt syndrome, a rare type of sarcoidosis, who had not received any immunosuppressants, including steroids, at the onset and who was clinically and radiologically responsive to the antiviral drug cidofovir.
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Authors
Takuya Yagi, Hidenori Hattori, Masayuki Ohira, Kazuo Nakamichi, Mutsuyo Takayama-Ito, Masayuki Saijo, Toshihiko Shimizu, Daisuke Ito, Kazushi Takahashi, Norihiro Suzuki,