Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3041738 | Clinical Neurology and Neurosurgery | 2008 | 4 Pages |
Abstract
Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all 11 reported FK506-associated polyneuropathies is given.
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Authors
Annick De Weerdt, Kristl G. Claeys, Peter De Jonghe, Dirk Ysebaert, Thiery Chapelle, Geert Roeyen, Philippe G. Jorens,