| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3042280 | Clinical Neurology and Neurosurgery | 2008 | 4 Pages |
Abstract
We report two brothers with a progressive cerebellar syndrome due to spinocerebellar ataxia type 8 (SCA8). In addition to severe cerebellar atrophy, both had prominent white matter hyperintensities on cranial MRI. This is the first report of white matter hyperintensities on cranial MRI in patients with SCA8. A disorder due to a similar molecular basis, myotonic dystrophy 1 (DM1), is known to have white matter hyperintensities on cranial MRI. Cognitive impairment is well described in DM1 and is being recognized in SCA8. The significance of these associations is discussed.
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Authors
Neeraj Kumar, Gary M. Miller,