Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3046451 | Clinical Neurophysiology | 2008 | 4 Pages |
ObjectiveTo examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).MethodsProlonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman suffering from ADNFLE with a CHRNA4 gene mutation.ResultsTwenty-seven of 30 recorded seizures started just after a K-complex. In nine cases a sound induced a K-complex that was immediately followed by the seizure. Most seizures preceded repetitive and brief ictal restarts.ConclusionsThree new characteristics have been observed in this ADNFLE patient: a K-complex is almost invariably present at seizure onset; sounds trigger some seizures; ictal restarts occur often.SignificanceThese new observations – the presence of K-complexes at seizure onset and occurrence of sound-triggered seizures – support the view that ADNFLE seizures may be initiated by K-complexes.