Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3047313 | Clinical Neurophysiology | 2008 | 12 Pages |
ObjectiveThe neural correlates of inhibitory deficits for emotional semantic material in persons with major depressive disorder (MDD) were investigated.MethodsIndividuals (n = 15) with a diagnosis of MDD or MDD in partial remission, and healthy controls (n = 14) underwent recording of event-related brain potentials (ERPs) while performing a computerized emotional Stroop task.ResultsThere were no group performance differences on the emotional Stroop task. However, the analysis of ERP waveforms revealed a larger negative wave peaking at about 170 ms over the left than the right hemisphere only in controls; a negative displacement (N450) at parietal sites for positive and negative words only for persons with MDD; in both groups, processing negative and positive words was associated with a positive displacement that peaked at about 450 ms and was larger over the left lateral frontal region; and, the N450 modulation correlated with negative automatic thinking and depressive symptoms.ConclusionsThe electrophysiological data reveal early changes in neural activity associated with word processing as well as valence-related changes in the N450 component at parietal sites in MDD.SignificanceThis valence-related increase in N450 amplitude at parietal sites may reflect an automatic capture of attention by words with emotional valence.