Article ID Journal Published Year Pages File Type
3048740 Clinical Neurophysiology 2006 7 Pages PDF
Abstract

ObjectiveTo study short interval intracortical inhibition (SICI) in a rare patient with segmental dystonia of the left upper limb due to a vascular lesion in the contralateral putamen without corticospinal tract involvement.MethodsPaired-pulse transcranial magnetic stimulation (TMS) was applied to both hemispheres in a conditioning-test paradigm. Six interstimulus intervals (ISIs) and 4 conditioning stimulation intensities were investigated in two separate sessions.ResultsMotor evoked potentials upon single-pulse TMS were within the normal range, whereas paired-pulse TMS revealed major changes in cortical excitability, proving that SICI was bilaterally absent.ConclusionsThe bilateral impairment of SICI cannot be considered the cause of dystonic contractions, but just a predisposing factor.SignificanceThe absence of SICI might be regarded as a condition able to promote maladaptive plastic changes triggered by focal lesions in the putamen.

Related Topics
Life Sciences Neuroscience Neurology
Authors
, , , , , , ,