| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3052094 | Epilepsy Research | 2013 | 5 Pages |
Abstract
SummaryA role of cholinergic nervous system in the behavioral impairments induced by repeated ECS is not understood. The α4β2 nicotinic acetylcholine receptor (nAChR) agonist ABT-418, but not the α7 nAChR agonist, significantly ameliorated the impairment of spontaneous alternation behavior in the Y-maze test. And, repeated ECS caused a reduction of α4 nAChR-positive cells in the prefrontal cortex and hippocampus. Thus, the α4β2 nAChR is related to ECS-induced deficits in rats.
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Authors
Noriaki Hidaka, Katsuya Suemaru, Yoshihisa Kato, Hiroaki Araki,