Anti-ictogenic effects of the corticotropin-releasing factor-like peptide in the pentylenetetrazole model of seizure in brain slices

•The MTX mini-peptide has shown anticonvulsant activity in the PTZ model of seizure.•MTX has long-term efficacy in inhibiting/suppressing ictal- and interictal-like activities.•MTX's protective effects were concentration- and time-dependent.•An enzymatic treatment of MTX is accompanied by a decrease in the frequency pattern EDs.

SummaryThe present study provides evidence for anti-ictogenic activity of the mystixin 7 (MTX) mini-peptide in the pentylenetetrazole model of seizure. MTX was effective in inhibiting/suppressing ictal- and interictal-like activities over a long period of time (during 60–80 min). The peptide's anti-ictogenic effects were concentration- and time-dependent. An enzymatic treatment of MTX was accompanied by a decrease of the frequency pattern of epileptiform discharges, but their total blockade did not occurred. These findings indicate that the MTX mini-peptide has pronounced anti-ictogenic properties.