Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3052295 | Epilepsy Research | 2012 | 10 Pages |
Abstract
In conclusion, the enhanced anticonvulsant action of phenobarbital and valproate by HMIPPS in the mouse maximal electroshock-induced seizure model, lack of pharmacokinetic interactions and no potential acute adverse effects make the combinations of HMIPPS with phenobarbital and valproate worthy of consideration for further experimental and clinical studies. The combinations of HMIPPS with carbamazepine and phenytoin are neutral from a preclinical viewpoint.
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Authors
Jarogniew J. Luszczki, Mateusz Kominek, Magdalena Florek-Luszczki, Dariusz A. Tchaytchian, Sergey L. Kocharov, Dorota Zolkowska,