| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3052424 | Epilepsy Research | 2011 | 4 Pages |
Abstract
SummaryTo assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p = 0.01) and a shorter half-life (p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
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Authors
Priscila Freitas-Lima, Veriano Alexandre Jr., Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, Americo Ceiki Sakamoto,