Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3052564 | Epilepsy Research | 2010 | 5 Pages |
Abstract
SummaryWe previously reported that low Mg2+ or 4-aminopyridine induced seizure-like events in organotypic hippocampal slice cultures (OHSCs) were resistant to standard antiepileptic drugs (Albus et al., 2008). We now show that high-frequency electrical stimulation induced ictal-like afterdischarges in OHSCs are effectively suppressed by the standard antiepileptic drugs phenytoin and carbamazepine. Thus, a single OHSC can express both pharmacoresistant and pharmacosensitive epileptiform activities.
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Authors
Abdul Wahab, Klaus Albus, Uwe Heinemann,