Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3052707 | Epilepsy Research | 2009 | 4 Pages |
Abstract
SummaryThe present study evaluated the development of tolerance to the anticonvulsant effect of morphine in a mouse model of clonic seizures induced by pentylenetetrazole, and whether ultra-low doses of the opioid receptor antagonist naltrexone which selectively block Gs opioid receptors were capable of preventing the observed tolerance. The results showed that the morphine anticonvulsant effect could be subject to tolerance after repeated administration. Both the development and expression of tolerance were inhibited by ultra-low doses of naltrexone, suggesting the possible involvement of Gs-coupled opioid receptors in the development of tolerance to the anticonvulsant effect of morphine.
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Authors
Maryam Roshanpour, Mehdi Ghasemi, Kiarash Riazi, Neda Rafiei-Tabatabaei, Mohammad Hossein Ghahremani, Ahmad Reza Dehpour,