Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3052825 | Epilepsy Research | 2009 | 4 Pages |
Abstract
SummaryA novel generation of silk-based brain implants engineered to release adenosine was recently shown to provide robust seizure suppression in kindled rats. As a first step to develop stem cell-coated silk-based 3D-scaffolds for the therapeutic long-term delivery of adenosine we engineered human mesenchymal stem cells (hMSCs) to release adenosine. Here we demonstrate reduction of chronic seizures in a mouse model of CA3-selective epileptogenesis after infrahippocampal transplantation of adenosine-releasing hMSCs.
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Authors
Tianfu Li, Gaoying Ren, David L. Kaplan, Detlev Boison,