| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3052981 | Epilepsy Research | 2008 | 4 Pages |
Abstract
SummaryAbnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC). These findings demonstrate a decrease both in GABA immunostaining (neuropil and neurons) and in GABA concentration (HPLC) in the CNIC of the epileptic hamster compared to control animals. These decreases may reflect a reduced availability of this neurotransmitter that may act as an audiogenic seizure-initiating factor.
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Authors
Verónica Fuentes-Santamaría, Juan Carlos Alvarado, Antonio S. Herranz, Natividad García-Atarés, Dolores E. López,